Active Community Research Projects


Intranasal Oxytocin for the Treatment of Autism Spectrum Disorders

Principal Investigator: Dr. Evdokia Anagnostou, Holland Bloorview  Kids Rehabilitation Hospital

Coordinator Contact: Rianne Hastie Adams, Study Coordinator
Holland Bloorview Kids Rehabilitation Hospital
Phone: 416-425-6220 x 6515

Purpose: To identify the effect of intranasal oxytocin (IN-OXT) versus placebo on social function in adults with ASD. The study aims to determine the safety and tolerability of IN-OXT, its effect on quality of life and anxiety, and whether or not it can improve core symptoms of ASD such as social cognition and responsiveness. We are doing this research because it is currently not known whether or not IN-OXT works for adults with ASD.

Who: 18-45 years old with ASD; Can tolerate venipuncture; Fluency in English; Able to provide written informed consent or able to provide written informed consent from their surrogate decision maker

This is a four-month randomized, double-blind, placebo-controlled trial of intranasal oxytocin for the treatment of adults with ASD who struggle with social functioning. You will be asked to come in to Holland Bloorview for a screening session. At this visit, we will talk with you, complete some behavioural tests and determine if you can safely participate in our research. If you meet eligibility criteria, you will be given a daily dose of oxytocin for the duration of the study. You will visit Holland Bloorview every two weeks for three months so that our research physicians can monitor your progress. There will also be one final follow up visit one month after you complete the study to ensure safety of oxytocin discontinuation and to look for possible maintenance of any favourable effects of oxytocin.


Working Together and Sharing Information on How to Support the Social Lives of Kids with Special Needs

Ryerson University

We  want  to  talk  to  kids  with  special  needs  and  their  parents  about:

1.  Their social experiences in the community

2.  What types of social activities or strategies they have tried

3.  What they perceive as important in their social life

Children and parents will receive a small thank you gift for participating in the study. Transportation costs will be reimbursed.

If interested, please contact:  Donna Koller, Associate Professor, Ryerson University, School of Early Childhood Studies.

416-­979-­5000 Ext. 2513,

Research  Team:  Donna  Koller, PhD, Ryerson University
                              Morgane Le Pouesard, MA, Ryerson University
                              Joanna  Anneke  Rummens,  PhD, University of Toronto
                              Jason  Nolan,  PhD,  Ryerson  University
                              Sharon Hope Irwin, PhD, SpeciaLink